受阻胺光稳定剂430的合成

摘要

针对现有受阻胺光稳定剂430的合成通常用双氧水作氧化剂而危险性较高的问题，探索了以叔丁基过氧化氢作氧化剂来合成受阻胺光稳定剂430的条件，设计了2条合成路线，分别以UV-3853及2，2，6，6-四甲基哌啶醇为原料，研究了溶剂、温度、催化剂等对反应的影响。结果表明：以叔丁基过氧化氢作氧化剂，一锅法以UV-3853为原料，MoO₃为催化剂，合成受阻胺光稳定剂430，收率可达76%；以2，2，6，6-四甲基哌啶醇为原料，经烷氧基化及酯交换反应得目标产物，总收率为63%。这2种合成方法均降低了实验的危险性，可尝试推广其工业应用。

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	马淑敏
	苏钰涵
	侯静茹
	陈立功
	闫喜龙
	李阳

关键词：受阻胺光稳定剂助剂430 叔丁基过氧化氢酯交换

Abstract：

At present, the synthesis of hindered amine light stabilizer 430 is generally used hydrogen peroxide as oxidant. Consequently, there are more risks in the synthesis. To solve this problem, we explored the conditions of the synthesis of hindered amine light stabilizer 430 with t-BuOOH (tert-butyl peroxide) as oxidant, designed two synthetic routes, and studied the effects of solvents, temperature, catalysts on the reaction. The results show that the target molecule can be obtained in one pot with t-BuOOH as oxidant, UV-3853 as reactant, MoO₃ as catalyst, and the yield can be up to 76%. In another route, after alkoxylation and transesterification, we can obtain the target molecule with 2,2,6,6-tetramethyl-piperidinol as reactant in 63% yield. These two synthetic methods reduce the danger of the experiments, and provide the potential of industrial application.

Keywords： hindered amine light stabilizer； assistant 430； tert-butyl peroxide； transesterification

Received 2016-11-25;

Corresponding Authors: 李阳,E-mail:liyang777@tju.edu.cn。 Email: liyang777@tju.edu.cn

About author: 马淑敏(1989-),女,硕士研究生,现从事手性小分子催化剂方面的研究。

引用本文:

马淑敏, 苏钰涵, 侯静茹, 陈立功, 闫喜龙, 李阳.受阻胺光稳定剂430的合成[J]. 化学工业与工程, 2018,35(1): 29-33

Ma Shumin, Su Yuhan, Hou Jingru, Chen Ligong, Yan Xilong, Li Yang.Synthesis of Hindered Amine Light Stabilizer 430[J]. Chemcial Industry and Engineering, 2018,35(1): 29-33

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