反式-4-羟基环己基地氯雷他定溶解度测定关联

摘要

采用高效液相色谱法测定了常压下在293.15~323.15 K温度范围内反式-4-羟基环己基地氯雷他定在水、质量分数为10% 的甲醇-水、质量分数为20% 的甲醇-水、质量分数为10% 的乙醇-水和质量分数为20% 的乙醇-水中的溶解度，并采用Apelblat方程和λh方程对所得到的溶解度数据进行关联拟合，通过van't Hoff方程计算了其在不同溶剂中的溶解焓和溶解熵。发现反式-4-羟基环己基地氯雷他定的溶解度随着温度的升高和溶剂极性的降低而升高，其溶解过程在实验温度范围内，在所选溶剂中均为吸热熵增过程。

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	薛童
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关键词：反式-4-羟基环己基地氯雷他定；溶解度； Apelblat方程； λh方程； van't Hoff方程

Abstract：

The solubility of trans-4-hydroxycyclohexyl desloratadine in water and the binary mixtures of 10% water+methanol, 20% water+methanol, 10% water+ethanol and 20% water+ethanol at the temperature range from 293.15 to 323.15 K at 101.3 kPa were measured using the HPLC (High Performance Liquid Chromatography) method. The obtained results were correlated with the modified Apelblat equation and the λh equation. Its enthalpy and entropy in the selected solvents were calculated based on the van't Hoff equation. It was found that the solubility of trans-4-hydroxycyclohexyl desloratadine increased with the increase of temperature, and decrease of polarity of solution. The dissolution processes in the above solvents were demonstrated to be an endothermic and entropy-driven over the investigated temperature range.

Keywords： trans-4-hydroxycyclohexyl desloratadine； solubility； Apelblat equation； λh equation； van't Hoff equation

Received 2015-06-05;

Corresponding Authors: 闫喜龙,E-mail:yan@tju.edu.cn。 Email: yan@tju.edu.cn

About author: 薛童(1989-),女,硕士研究生,从事精细化工方向的研究。

引用本文:

薛童, 张日成, 闫喜龙.反式-4-羟基环己基地氯雷他定溶解度测定关联[J]. 化学工业与工程, 2017,34(3): 30-36

Xue Tong, Zhang Richeng, Yan Xilong.The Solubility Measurement and Correlation of Trans-4-Hydroxycyclohexyl Desloratadine[J]. Chemcial Industry and Engineering, 2017,34(3): 30-36

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