pH响应性聚合物修饰的空心介孔硅球的制备

摘要

将有机硅RAFT试剂三甲氧基硅基丙基三硫代羰基苄基酯（BTPT）固载于硅球表面，通过可逆加成-断裂链转移自由基聚合表面接枝法制备了pH值、温度双敏感聚合物聚甲基丙烯酸-2-（二甲氨基）乙酯（PDMAEMA）修饰的纳米硅球，通过表面保护法在常温下用氨水对该修饰过的硅球进行刻蚀，制得PDMAEMA修饰的纳米空心介孔硅球（HMS@PDMAEMA）。通过核磁、红外、GPC和透射电子显微镜等方法对其结构和表面形貌进行了表征，并用纳米粒度及zeta电位仪测试了其pH值响应行为，预测HMS@PDMAEMA在癌症药物的控制释放和基因递送等领域具有潜在的应用价值。

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	钟庆
	张建华
	郭睿威

关键词：纳米空心介孔硅球；表面修饰；聚合物； pH值响应性

Abstract：

Trimethoxysilyl-propyl-trithiocarbonyl-benzyl ester(BTPT), which is one of the silicone-based RAFT agents, was grafted onto the surface of silica nanospheres. Using the reversible addition-fragmentation chain transfer polymerization, silica nanospheres modified with the pH-and temperature-sensitive polyelectrolyte poly(N, N-dimethylaminoethyl methacrylate) (PDMAEMA) were prepared. Then silica nanospheres grafted with PDMAEMA were transformed to the hollow mesoporous structure by surface-protected etching strategy using ammonia at ambient temperature, thereby obtained the hollow mesoporous silica nanospheres modified with the PDMAEMA (HMS@PDMAEMA). The resultant composite nanoparticles with pH-and temperature-sensitive polymer shell and HMS core were characterized by a variety of techniques such as ¹HNMR, FTIR, GPC and TEM, etc. The pH-sensitive behavior was tested by nano-size and zeta potential analyzer. We envision that the HMS@PDMAEMA should have potential applications in controlled release of anticancer drug and gene delivery.

Keywords： hollow mesoporous silica nanoparticles； surface modification； polymer； pH-sensitive behavior

Received 2015-04-21;

Corresponding Authors: 郭睿威,E-mail:rwguo@263.net。 Email: rwguo@263.net

About author: 钟庆(1989-),男,硕士研究生,现从事化学工程方向的研究。

引用本文:

钟庆, 张建华, 郭睿威.pH响应性聚合物修饰的空心介孔硅球的制备[J]. 化学工业与工程, 2017,34(2): 50-54

Zhong Qing, Zhang Jianhua, Guo Ruiwei.Facile Preparation of Hollow Mesoporous Silica Nanoparticles Coated with pH-Sensitive Polymer[J]. Chemcial Industry and Engineering, 2017,34(2): 50-54

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