硫辛酸钠的表面活性对制备无溶剂硫辛酸的影响

摘要

对硫辛酸制备工艺中水相法纯化过程进行了研究，结果表明硫辛酸钠具有表面活性，若其浓度高于临界胶束浓度，则会加剧硫辛酸聚集，不利于结晶，进而发生聚合反应生成黏稠物质。因此，需要加大水量，降低硫辛酸钠的浓度，当浓度低于临界胶束浓度时，收率会大幅增加。采用电导法测定硫辛酸钠的临界胶束浓度为0.253 mol/L，对应的水量为19.2倍，这与测定硫辛酸水量与收率关系的工艺实验得到的最适宜水量正好吻合。

	Service

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	Email Alert
	RSS
	作者相关文章
	陈国斌
	陶乃敏
	冯荣秀

关键词：硫辛酸钠；表面活性；临界胶束浓度；硫辛酸

Abstract：

The process of purifying lipoic acid in water was studied in this paper. The surface activity of lipoic acid sodium was detected, which had a great effect on preparation of solvent-free lipoic acid. When the concentration of lipoic acid sodium was above the critical micelle concentration (CMC), micelles would be formed. Lipoic acid was wrapped up in the micelles, which was not conducive to crystallization and the polymerization of lipoic acid could be performed more easily. When the concentration of lipoic acid sodium was reduced to below the CMC by adding more water, the yield of lipoic acid would be increased obviously. The CMC of lipoic acid sodium was 0.253 mol/L which was measured by the conductivity method, and the corresponding quantity of water was 19.2 times. The result was in agreement with the best quantity of water in the purification experiments.

Keywords： lipoic acid sodium； surface activity； critical micelle concentration； lipoic acid

Received 2015-02-09;

Corresponding Authors: 冯荣秀,E-mail:rxfeng7091@tju.edu.cn。 Email: rxfeng7091@tju.edu.cn

About author: 陈国斌(1980-),男,硕士,工程师,研究方向为医药及精细化工。

引用本文:

陈国斌, 陶乃敏, 冯荣秀.硫辛酸钠的表面活性对制备无溶剂硫辛酸的影响[J]. 化学工业与工程, 2016,33(4): 91-94

Chen Guobin, Tao Naimin, Feng Rongxiu.Effect of Surface Activity of Lipoic Acid Sodium on Preparation of Solvent-Free Lipoic Acid[J]. Chemcial Industry and Engineering, 2016,33(4): 91-94

[1] Lester J R, Betty G D, Gunsalus I C,et al. Crystalline α-lipoic acid: A catalytic agent associated with pyruvate dehydrogenas[J]. Science, 1951, 114(2 952): 93-94
[2] 沙大年, 范小兵, 张迪, 等. 生物抗氧化剂α-硫辛酸[J].中成药, 1999, 21(12): 655-657 Sha Danian, Fan Xiaobing, Zhang Di, et al. Biological antioxidant α-lipoic acid[J]. Chinese Traditional Patent Medicine, 1999, 21(21): 655-657(in Chinese)
[3] Giray G,Huthmacher K,Kleemann A, et al. Process for the production of 1,2-dithiolan-3-pentanoic acid(thioctic acid) and intermediate compounds therefor: US, 4705867[P]. 1987-11-10
[4] 李传莹. α-硫辛酸的合成[D]. 浙江:浙江大学,2002 Li Chuanying. Synthesis of α-Lipoic Acid[D]. Zhejiang: Zhejiang University, 2002(in Chinese)
[5] Trujillo M, Radi R. Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: New insights into the reaction of peroxynitrite with thiols[J]. Archice of Biochemistry and Biophysics, 2002, 397(1): 91-98
[6] Beisswenger T, Bethge H, Goede J,et al. RS-Thiocetic acid with novel morphology: US, 5455264[P]. 1995-10-03
[7] Segre A, Viterbo R, Parisi G. A new synthesis of 6-thhioctic acid (DL-α-lipoic acid)[J]. Journal of the American Chemical Society, 1957, 79(13): 3 503-3 505
[8] Ose H, Yoshida K. Synthesis of thioctic acid and thioctic acid amine: US, 3223712[P]. 1965-12-14
[9] 刘刚, 孙琳, 刘春萍, 等. 水相中无溶剂α-硫辛酸的制备[J]. 广州化工, 2008, 36(1): 1-3 Liu Gang, Sun Lin, Liu Chunping, et al. Preparation of α-lipoic acid without solvent in water[J]. Guanzhou Chemical Industry, 2008, 36(1): 1-3(in Chinese)
[10] Schuhbauer H, Winkler S, Gruber A. Method for the production of a solvent-free α-lipoic acid: US, 6462202[P]. 2002-08-08
[11] Takahashi H, Bungo Y, Mikuni K. The aqueous solubility and thermal stability of α-lipoic acid are enhanced by cyclodextrin[J]. Bioscience, Biotechnology and Biochemistry, 2011, 75(4): 633-637
[12] 武丽艳, 尚贞锋, 赵鸿喜. 电导法测定水溶性表面活性剂临界胶束浓度实验的改进[J]. 实验技术与管理, 2006, 23(2): 29-30 Wu Liyan, Shang Zhenfeng, Zhao Hongxi. Improving the experiment of water solubility surface active agents critical concentration by the conductive method[J]. Experimental Technology and Management, 2006, 23(2): 29-30(in Chinese)