吡唑醚菌酯的合成研究

摘要

以邻硝基甲苯为原料,经还原、酰化、甲基化和溴化四步反应得到N-甲氧基-N-2-溴甲苯氨基甲酸甲酯,然后与1-(4-氯苯基)-3-吡唑醇反应得到吡唑醚菌酯。在优化后的反应条件下,目标化合物纯度大于98.4%(LC),总收率大于56.7%(以邻硝基甲苯计),其结构经¹H-NMR和MS分析确证。该工艺具有反应条件温和,产品收率高等优点,适合工业化生产。

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	李清
	李巍
	刘东志
	周雪琴

关键词：吡唑醚菌酯；邻硝基甲苯； 1-(4-氯苯基)-3-吡唑醇；合成

Abstract：

Pyraclostrobin was synthesized by reaction of methyl N-methoxyl-N-2-bromine toluene carbamate with 1-(4-chlorophenyl)-3-hydroxypyrazole, methyl N-methoxyl-N-2-bromine toluene carbamate was prepared from o-nitrotoluene by reduction, acylation, methylation, and bromination four steps. Under the optimal condition, the purity was 98.4%(LC), and the total yield was 56.7% based on o-nitrotoluene. The structure of the prepared product was confirmed by ¹H-NMR and MS. The process exhibites mild reaction conditions and high yield, and is suitable for industrial production.

Keywords： pyraclostrobin； o-nitrotoluene； 1-(4-chlorophenyl)-3-hydroxypyrazole； synthesis

Received 2013-12-04;

Corresponding Authors: 李巍, E-mail: liwei2008@tju.edu.cn。 Email: liwei2008@tju.edu.cn

About author: 李清(1987-),女,硕士研究生,主要研究方向为精细化工合成。

引用本文:

李清, 李巍, 刘东志, 周雪琴.吡唑醚菌酯的合成研究[J]. 化学工业与工程, 2016,33(1): 45-50

Li Qing, Li Wei, Liu Dongzhi, Zhou Xueqin.Synthesis of Pyraclostrobin[J]. Chemcial Industry and Engineering, 2016,33(1): 45-50

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