壳聚糖-端羧基聚酰胺胺接枝物的合成与性能

摘要

以乙二胺、丙烯酸甲酯为原料,采用迈克尔加成反应和水解反应制备端羧基聚酰胺胺.在1-(3-二甲氨基丙基)-3-乙基碳二亚胺盐酸盐(EDC)和N-羟基琥珀酰亚胺(NHS)的催化下,合成了壳聚糖-端羧基聚酰胺接枝物.分别使用红外光谱和热重分析法对目标产物进行了表征,并通过对接枝产物的水溶性以及粒径的研究确定了合成最适宜投料比.根据透射电镜图像,提出了该接枝物的成球机理.

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	张晓洋
	赵峻
	姚芳莲

关键词：壳聚糖；端羧基聚酰胺胺；自组装；核壳纳米颗粒

Abstract：

Terminal carboxyl group-poly(amidoamine) (PAMAM) was synthesized by the Michael addition reaction of methyl acrylate and ethylenediamine,followed by the hydrolysis of terminal ester groups to carboxyl group. Chitosan-grafted-terminal carboxyl groups poly(amidoamine)(CS-g-PAMAM) was prepared via amidation reaction of chitosan and terminal carboxyl group-PAMAM in the presence of EDC/NHS. The resultant products were characterized by nuclear magnetic resonance spectroscopy and thermogravimetric analysis respectively. The optimal feeding ratio was determined by the study about the water-solubility and size of the resultant CS-g-PAMAM nanopartilces. The morphology of CS-g-PAMAM in water was observed by TEM and a formation mechanism of CS-g-PAMAM core-shell nanoparticles was proposed.

Keywords： chitosan； terminal carboxyl group-poly(amidoamine)； self-assembly； core-shell nanoparticles

Received 2013-05-22;

Corresponding Authors: 姚芳莲,E-mail: yaofanglian@tju.edu.cn. Email: yaofanglian@tju.edu.cn

About author: 张晓洋(1988-),男,硕士研究生,研究方向为壳聚糖基纳米生物材料.

引用本文:

张晓洋, 赵峻, 姚芳莲.壳聚糖-端羧基聚酰胺胺接枝物的合成与性能[J]. 化学工业与工程, 2015,32(6): 31-35

Zhang Xiaoyang, Zhao Jun, Yao Fanglian.Synthesis and Properties of Chitosan-g-Terminal Carboxyl Group-Poly(amidoamine)[J]. Chemcial Industry and Engineering, 2015,32(6): 31-35

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