（School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Key Laboratory of Systems Bioengineering, Ministry of Education, Tianjin 300072, China）
Abstract：
The present paper introduces recent progress in Tacrolimus’s physical and chemical characteristics as well as immunosuppressant activity in detail. For this purpose, the paper mainly summarizes research on fermentation production technology, the biosynthesis gene clusters and metabolic pathways. Furthermore, some successful cases of improvement about production of Tacrolimus based on metabolic engineering technology are reviewed. In future, the combination of systems biology and synthetic biology would provide rational guidance to promote the production efficiency of Tacrolimus and construct the high-yield producing strains with the improved key enzymes.
2014, Vol. 31 
