桉叶油微乳用于经皮给药的研究与评价

摘要研究与评价了桉叶油作为油相在经皮给药微乳中的有效性。试验以非洛地平作为模型药物。分别以油酸、肉豆蔻酸异丙酯（IPM）和桉叶油为油相制备了9个水包油微乳处方，通过测定各处方物理化学参数和大鼠体外透皮试验研究，通过对比载药量、透皮速率、滞后时间等参数，得到最适宜的处方：w(桉叶油)为5%，、w(吐温-80)为27.5%、w(乙醇)为27.5%和w(水)为40%。最后对该处方进行了兔子在体皮肤刺激性研究。结果表明桉叶油有着显著的优点：乳化能力强、对亲脂药物溶解度大、透皮促进效果明显、稳定性好。但是桉叶油也有一定皮肤刺激性，不宜用量过大。

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	邱少峰
	李德馨
	魏振平

关键词：桉叶油微乳经皮皮肤刺激

Abstract： The effectiveness of eucalyptus oil microemulsion in transdermal drug delivery system was evaluated. Felodipine was used as model drug. Nine o/w microemulsion formulations were prepared using oleic acid, IPM and eucalyptus oil as oil phases respectively. The physicochemical parameters were measured and skin permeation experiment in vitro was investigated. The drug loading, permeation rate and lag time were compared and optimized formulation was composed of eucalyptus oil (5%, w/w), Tween 80 (27.5%, w/w), ethanol (27.5%, w/w) and water (40%, w/w). And the skin irritation study was performed using the optimized formulation. The eucalyptus oil showed high emulsification capacity, high solubility of lipophilic drugs, high permeation enhancement effect and good stability. However, eucalyptus oil possessed a certain skin irritation, so it should not be excessive.

Keywords： eucalyptus oil microemulsion transdermal skin irritation

Received 2012-04-24;

Corresponding Authors: 魏振平，电话：（022）27890336，E-mail：zpwei2000@sina.com。 Email: zpwei2000@sina.com

About author: 邱少峰（1987-），男，现从事药物制剂技术，药物新剂型的研究。

引用本文:

邱少峰, 李德馨, 魏振平.桉叶油微乳用于经皮给药的研究与评价[J]. 化学工业与工程, 2013,30(3): 44-49

QIU Shao-Feng, LI De-Xin, WEI Zhen-Ping.Evaluation of Microemulsion Using Eucalyptus Oil in Transdermal Drug Delivery System[J]. Chemcial Industry and Engineering, 2013,30(3): 44-49