Abstract：
Chitosan, who has a great storage in nature, has a lot of advantages such as non-toxicity, biodegradability, biocompatibility and cytocompatibility. Therefore, it receives much attention in the field of biomedicine. In this article, high efficiency photo crosslinked hydrogel was prepared through the conjugation of 4-azidobenzoic acid with chitosan chains. To confirm the conjugation, methods of FT-IR and 1H-NMR were employed. In order to have a deep understand of the properties of the hydrogels, tests of water loss rate, vapor transmittance and drug release were carried out, which especially focused on evaluating the influence of substitution degree of azides on properties of hydrogels. Results showed that, the substitution degree had certain influence on properties of hydrogels. Through understing of the influence, hydrogels can be made according to the requirements of the application areas.
SUN Da, WANG Hui, ZHU Chuan-Shun, YAO Fang-Lian.Evaluation of the Influence of Substitution Degree on Properties of Chitosan Based Photo-Crosslinked Hydrogel[J]. Chemcial Industry and Engineering, 2012,29(6): 11-15
2012, Vol. 29 
