Application of Nanotechnology in the Development of Pharmaceutical Preparations
GAO Jie1, LIAN Xiao-Yan2, WEI Zhen-Ping3, WANG Bo2, LI Hong-Qi2, REN Xiao-Wen2
1.��Graduate school, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China�� 2.��Tianjin Institute of Pharmaceutical ��
Research, Tianjin 300193, China�� 3.��School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China
Abstract��
The lower bioavailability caused by poor water solubility is one of the important factors that hurdled the development and reasonable use of the pharmaceutical APIs. However, with the application of the nanotechnology in the development of pharmaceutical preparations, the bioavailability for some of the poorly water��soluble drugs had been greatly improved. In this article, applications of nanotechnology were introduced in pharmaceutical preparations as dosage��forms of microemulsion, solid lipid nanoparticles, nanogel, polymeric nanoparticle and nanocrystals. The possible problems resulted from the use of nanopreparations were discussed together with their advantages over the traditional dosage��forms with the purpose of expanding the application of nanotechnology in the R&D of novel pharmaceutical preparations.��
GAO Jie, LIAN Xiao-Yan, WEI Zhen-Ping, WANG Bo, LI Hong-Qi, REN Xiao-Wen.Application of Nanotechnology in the Development of Pharmaceutical Preparations[J]. Chemcial Industry and Engineering, 2012,29(5): 64-69
2012, Vol. 29 
